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Cefpodoxime for Dogs Guide [2023 Dosage & Side Effects]

Dog skin infection is a common health problem for our furry pals. Skin infection can drive dogs crazy, the sight of a scratching dog can make every caring owner miserable. One of the major reasons owners take their dogs to the vet is to seek relief from these infections.

What makes it worse is that antibiotics that have long been an important part of treating skin infections are losing the fight against drug-resistant bacteria. Especially staph strains bacteria commonly associated with canine skin infections. Cefpodoxime for dogs is a 3rd generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms.

cefpodoxime for dogs

cefpodoxime moleculeIf you find yourself in this situation, read on as we reveal the ideal medication that will solve your dog’s skin problem and bring her skin back to normal. The good news is that cefpodoxime is a very effective antibiotic that can be used to treat canine skin infections. It is effective against a wide range of bacteria. In this article, we will discuss everything you need to know about cefpodoxime for dogs. So read on and find out if cefpodoxime is a suitable option for your dog’s skin infection.

  1. Chewy CefpodoximeProxetil (Generic) Tablets for Dogs-
  2. Cefpoderm Tablets for dogs
  3. Simplicef (CefpodoximeProxetil) Tablets for Dogs (100mg)
  4. Walmart Cefpoderm Tablet for Dogs
  5. Walmart Simplicef Tablet for dogs
  6. Cefpodoxime Tabs 200 mg, 100 Tablets

What is cefpodoxime for dogs?

Cefpodoxime for dogs is a broad-spectrum antibiotic used to treat various bacterial infections in dogs. It belongs to the cephalosporin family of antibiotics and works by inhibiting the growth of bacteria. Cefpodoxime is usually administered orally or injected directly into the affected area, depending on the treatment’s severity and type of infection.

Cefpodoxime treats various bacterial infections in dogs, such as skin and soft tissue infections, urinary tract infections, and respiratory tract infections. It is also sometimes used to treat more serious conditions, such as sepsis and meningitis. In some cases, cefpodoxime may be used as an alternative to other antibiotics if the infection is resistant to the usual treatment.

Cefpodoxime is generally well tolerated by dogs and has minimal side effects. Common side effects include nausea, vomiting, and diarrhea. If these symptoms persist, contact your veterinarian. Cefpodoxime may also interact with other medications, so it is important to talk to your veterinarian about any other medications your dog takes.

Overall, cefpodoxime is an effective broad-spectrum antibiotic used to treat various bacterial infections in dogs. It is generally well tolerated and has minimal side effects. Still, talking to your veterinarian about any other medications your dog takes to avoid any potential interactions is important.

What does cefpodoxime for dogs look like?

Cefpodoxime is available in tablets, capsules, and as an oral suspension. The tablets and capsules have various strengths, usually ranging from 20 mg to 200 mg. The oral suspension contains 20 mg of cefpodoxime per 5 mL (1 teaspoon). Cefpodoxime tablets are round, white, and marked on one side. The capsules are also round but light yellow and have no markings. The oral suspension is a light yellow-colored liquid and should be shaken before use.

A veterinarian usually prescribes Cefpodoxime for skin, urinary tract, and respiratory infections. It is important to follow the veterinarian’s instructions for dosage and administration. Cefpodoxime should be given with food and not taken on an empty stomach. Dogs should not be allowed to lick the medication off their fur or paws, as this can cause them to ingest too much of the antibiotic.

dog scratching

How does cefpodoxime for dogs work?

Cefpodoxime is the active substance in a drug referred to as cefpodoxime proxetil. Cefpodoxime for dogs works by killing the bacteria that cause the infection or preventing them from reproducing. Cefpodoxime belongs to a class of antibiotics called cephalosporins, which are related to penicillins. Cefpodoxime works by interfering with the cell wall synthesis of bacteria. This prevents the bacteria from growing and reproducing, eventually leading to their death. Cefpodoxime also works by inhibiting the bacteria’s ability to produce certain proteins that are necessary for their survival.

When taking cefpodoxime, it is important to give your dog the full course of treatment, even if the symptoms of the infection appear to go away. This is important because not finishing the full course of antibiotics can lead to antibiotic resistance. This means that the antibiotic may not work as well in the future or may not work at all.

What are the infections treated with cefpodoxime?

Cefpodoxime is commonly used to treat different kinds of skin infections in dogs and puppies older than 18 days. It can also be used to treat respiratory and urinary tract infections (dog food for UTI). The United States Food and Drug Administration (FDA) has approved the use of products containing Cefpodoxime in dogs. The body authorizes veterinarians to recommend and use products containing Cefpodoxime in different species of dogs. Cefpodoxime’s ability to reach different areas of the body makes it a good choice for treating various infections. The following are dog conditions commonly treated with cefpodoxime include:

  • Ear infection
  • Skin infection
  • An upper respiratory infection
  • Urinary tract infection

Is cefpodoxime a strong antibiotic?

Cefpodoxime is a third-generation antibiotic known as cephalosporins. The first generation of cephalosporins was developed around the 1960s to overcome the antibiotic resistance that microorganisms had developed in reaction to medication like penicillin. Cephalosporins worked just like penicillins but were very active against antibiotic-resistant bacteria. Though these first cephalosporins were a major improvement over penicillins, bacteria continued to advance and soon developed new means of resistance. So, the second and third-generation cephalosporins were developed to provide a broader spectrum of activity against bacteria that may resist other antibiotics.

How long does it take for cefpodoxime to work in dogs?

Cefpodoxime eliminates sensitive bacteria by attacking the cell wall. It is extremely resistant to attack by bacterial enzymes, which makes it effective in several conditions where other antibiotics are not effective. The medication should start working within 1 to 2 hours, although you may not see the effects of this drug externally. Your furry pal should start recovering in a day or two. The effects of this drug are short-lived, meaning that it will stop working within 24 hours, though the benefits may be prolonged if your dog has decreased kidney.

What are the side effects of cefpodoxime for dogs?

Cefpodoxime proxetil for dogs is just like most other medications out there and has the potential to cause side effects. Some dogs vomit shortly after taking cefpodoxime proxetil. Dogs may experience the following side effects of taking cefpodoxime:

  • diarrhea,
  • decreased appetite,
  • shortness of breath, and
  • facial swelling.

Tiredness is also a possibility. If you are breeding your dog, already pregnant or presently nursing puppies, discuss with your vet about any potential problems these conditions could introduce. Inform your veterinarian if your dog is using other medications or has ever experienced any problems with any cephalosporin or penicillin medications. Dogs allergic to cefpodoxime should not take it. Consult your veterinarian immediately if you have any questions about cefpodoxime’s side effects on your dog.

If your dog experiences significant side effects from cefpodoxime, get in touch with your veterinarian to determine the best course of action for your furry pal. If the side effect is severe, or you suspect an allergic reaction or overdose, make sure you contact your vet immediately, as it could be an emergency situation.

You can also consult the Pet Poison Helpline and the ASPCA’s Animal Poison Control Center if you suspect that your dog has overdosed on the medication. Like with other medications, for example, trazodone-for-dogs, always follow the guidelines and look for any side effects.

dog having it's check up

Cefpodoxime Dosages for Dogs

CefpodoximeProxetil is a prescription for dogs to treat bacterial skin infections, wounds, and abscesses, including bladder and respiratory infections. This drug can easily be hidden in your dog’s favorite food since it comes in an uncoated tablet form. Cefpodoxime dosage for dogs is once a day. Your vet will decide the right dose for your pup, depending upon your puppy’s weight and the condition that requires treatment. It is important to give this medication as directed.

Administer the entire drug that is recommended for your dog, even when his condition appears to have resolved. Discontinuing your dog’s antibiotic treatment quickly can lead to antibiotic-resistant infections. Cefpodoxime can be given with food or on an empty stomach.

Cefpodoxime proxetil tablets should be given once a day for five to seven days or for two to three days after the cessation of clinical symptoms, up to a maximum of 28 days. Treatment of severe infections should not be continued for more than three to four days if there is no response to treatment. The following table offers guidelines for daily dosing of cefpodoxime. Make sure you follow all of your vet’s instructions.

Cefpodoxime for dogs Tablets at 2.3 mg/lb Total Daily Dosage

Weight No. of 100 mg Tablets No. of 200 mg Tablets
22 lbs. .5
44 lbs. 1
66 lbs. 1.5
88 lbs. 1
132 lbs. 1 1

 Cefpodoxime Tabs at 4.5 mg/lb Total Daily Dosage

Weight No. of 100 mg Tablets No. of 200 mg Tablets
11 lbs. .5
22 lbs. 1
44 lbs. 1
66 lbs. 1 1
88 lbs. 2
132 lbs. 3

The major benefits of cefpodoxime for dogs

Compared to other products, cefpodoxime is a commonly used antibiotic in veterinary medicine, if you are wondering. The following are some of the major benefits of Cefpodoxime proxetil for dogs:

  • It is effective against a wide variety of bacteria and can be used to treat infections in dogs.
  • Cefpodoxime can be administered to both dogs and cats
  • Cefpodoxime takes a long time to break down in the body. This means that for most dogs, one pill a day is enough.
  • The tablets are scored, coated, and odorless. This means that most dogs will easily eat them.
  • Unlike many other antibiotics, cefpodoxime can be given with or without food.

Prevention is always better than trying to fix the problem. When you groom your dog look for potential skin problems and deal with potential issues as soon as you can.

Cefpodoxime for dogs: available products

Now that you have a good understanding of this medication and you now feel more confident that Cefodoxime could be an excellent choice for your dog’s skin infection. It is best to consult your veterinarian before using cefpodoxime to treat a dog infection problem. The following are the in-depth reviews on the best cefpodoxime products along with their pros and cons. If you know what you need, here are quick links to the products.

1. Chewy CefpodoximeProxetil (Generic) Tablets for Dogs

cefpodoxime proxetil generic tablets for dogsCefpodoximeproxetil tablets are used for the treatment of bacterial skin infections. Including wounds and abscesses, as well as bladder and respiratory infection in dogs. It comes in an uncoated tablet form and can be easily concealed in your dog’s favorite food for easy administration. The following are the pros and cons of cefpodoxime proxetil for dogs.


  • It has an excellent price tag
  • It’s easy to hide in your dog’s favorite food.
  • It is also used in the treatment of bladder and respiratory infections in dogs.
  • It treats bacterial infections by suppressing the growth of microorganisms.


  • It is not suitable for dogs allergic to cephalosporins or penicillins.

2. Cefpoderm Tablets for dogs

cefpoderm cefpodoxime proxetil tablets for dogsCefpoderm tablet is an oral drug used to treat dog skin infections caused by susceptible strains of Staphylococcus aureus, Escherichia coli, Streptococcus canis, Pasteurella multocida, and Staphylococcus intermedius. If your furry pal has a skin infection, wound, or abscess, your veterinarian may recommend Cefpoderm tablets to treat your dog’s skin infection. Cefpoderm Tablets are easy to administer to your dog and should only be given once a day.

This tablet can also help treat respiratory and bladder infections in dogs. Helping them to quickly recover to their normal, happy, and healthy selves. The following are the pros and cons of Cefpoderm tablets for dogs.


  • It treats skin, respiratory, and bladder infections in dogs.
  • It can be administered with or without food
  • It helps dogs to quickly return back to their normal self
  • Simple oral once-daily dosing
  • It comes in a film-coated tablet for easy administration.


  • It is not suitable for pregnant or nursing dogs.

3. Simplicef (Cefpodoxime Proxetil) Tablets for Dogs (100mg)

simplicef cefpodoxime proxetil tablets for dogsCefpodoxime 100mg tablets for dogs are used to treat various infections in dogs caused by both Gram-positive and Gram-negative bacteria. These infections include urinary tract, skin, bone, and respiratory tract infections. The good thing about this antimicrobial is that it comes in a tablet shape, therefore you can feed it orally. The following are the pros and cons of Simplicef tablets for dogs.


  • It is used to treat several kinds of infections with mild side effects.
  • It is taken two times a day, compared to some of the more frequently taken alternatives.
  • cefpodoxime 100mg for dogs is available in a tablet and liquid form
  • Since it comes in tablet form, you can feed your dog orally.
  • It is ideal for treating skin infections such as wounds and abscesses in dogs.


  • It is not suitable for pregnant or lactating dogs.
  • Not good for dogs with seizure disorders, epilepsy, and kidney disease.

4. Walmart Cefpoderm Tablet for Dogs

cefpoderm cefpodoxime proxetil tablet rxCefpodoximeProxetil is an antibiotic tablet that helps in treating dog skin infections. It is also effective in treating respiratory and bladder infections in dogs. CefpodoximeProxetil is easy to administer on a once-daily, oral tablet. The following are the pros and cons of the Cefpoderm Tablet for Dogs.


  • FDA approved for the treatment of bacterial skin infections in dogs
  • Simple doses once a day
  • It can be taken with or without food.


  • It can cause allergic reactions in sensitized dogs

amazon button yellow


5. Walmart Simplicef Tablet for dogs

simplicef tablet rxSIMPLICEF is the first once-a-day oral cephalosporin that has been approved by the FDA for vets. To use in the treatment of dog skin infections caused by susceptible strains of Streptococcus aureus, Pasteurella multocida, Escherichia coli, and Proteus mirabilis. It is made to be convenient and of good value for dogs. The following are the pros and cons of Simplicef tablets for dogs.


  • It can also be used in treating other types of infections, such as ear and urinary tract infections in dogs.
  • It is also effective in treating respiratory tract infection
  • It is designed to be convenient when giving your dogs.
  • This is the first oral once-daily cephalosporin that has been approved by the FDA for veterinary use in the treatment of dog skin infections.


  • It can cause poor appetite in some dogs.

amazon button yellow


6. Cefpodoxime Tabs 200 mg, 100 Tablets

cefpodoxime tabs 200cefpodoxime 200 mg for dogs is a cephalosporin antibiotic approved by the FDA to treat skin infections such as wounds and abscesses in dogs. This particular drug is the generic equivalent of Simplicef 200mg tablets. Since cefpodoxime is less expensive than Simplicef. You can save more while continuing to treat your dog’s infection. These tablets are effective against strains of Staphylococcus aureus, Streptococcus canis, Pasteurellamultocida, Escherichia coli, and Proteus Proteus. cefpodoxime 200 mg for dogs is effective in treating bacterial infections in dogs.


  • It is excellent antibiotic for dogs
  • It treats a variety of infections, such as skin, urinary tract, respiratory infections in dogs.
  • It is an easy medication regimen for dogs
  • It can be given with or without food


  • The safety of this drug is not confirmed for breeding, pregnant, or lactating dogs.

check price button yellow


FAQ’s About Cefpoderm for dogs

Explore the questions below to learn the basics of Cefpodoxime, its use, and the possible side effects. Cefpodoxime is essential to combat canine skin infections. This is the most effective way to treat a bacterial infection in dogs. These Frequently Asked Questions (FAQs) remove some confusion and provide you with science-based information to help you make informed decisions about cefpodoxime for dogs.

Can humans take cefpodoxime?

Cefpodoxime is accepted to treat bacterial infections in humans. You may be familiar with this medication because your furry pal got it from a veterinarian. Do not take cefpodoxime unless your healthcare provider recommends it for you. Human and pet medications are not always made the same, therefore a dog’s supply of cefpodoxime may not be suitable for a human, and your cefpodoxime supply may not be suitable for your dog.

How should I store cefpodoxime?

The safe storage of cefpodoxime proxetil is something every dog owner should be aware of. Knowing how to safely store your medications is an essential part of treatment. Although cefpodoxime is designed to treat infections, it can cause great harm. A few simple safety measures can help protect your furry pals. Store cefpodoxime proxetil tablets away from heat and light between 68 ° F and 77 ° F (20-25 ° C). Liquid suspensions should be cooled between 35°F and 45°F (2°C-8°C) for up to 2 weeks.

What if I miss giving my pet the medication?

Life gets busy and we often forget to take our medicines, not to mention giving our dogs their daily dosage. Missing your dog’s medication can have serious consequences depending on the treatment for your dog. If you skip a dose, give it once you remember. But if it is time for the next dose, forget the missed dose and give it at the next scheduled time and continue your usual dosing plan. Do not give your dog more than one dose at a time or provide extra doses.

dog skin infections cefpodoxime for dogs

Which is better amoxicillin or cefpodoxime?

Cefpodoxime and amoxicillin are different kinds of antibiotics. Cefpodoxime is a cephalosporin antibiotic and amoxicillin is a penicillin-type antibiotic. Cefpodoxime has been shown to be better than amoxicillin in treating severe skin infections in dogs. Cefpodoxime produces a much superior clinical treatment rate than amoxicillin. Cefpodoxime is used to treat bacterial infections in different parts of the body. It belongs to the class of medication known as cephalosporin antibiotics.

What should I do in an emergency situation?

If you think that your furry pal is experiencing an adverse reaction due to cefpodoxime proxetil, or has overdosed. Contact your veterinarian or emergency veterinary hospital without delay. Signs of a cefpodoxime overdose include diarrhea, vomiting, jaundice; it can also lead to decrease appetite and lethargy.

Are there any risk factors for this medication?

Cefpodoxime is not recommended for dogs that are allergic to it or to other cephalosporins. It should be used with care in dogs with a history of seizures or kidney disease. Cefpodoxime should only be used during pregnancy with vet recommendations if necessary and should be used with carefulness in lactating dogs.

Are there any drug interactions I should be aware of?

If your veterinarian has directed you to use cefpodoxime. Your veterinarian may already be aware of any potential drug interactions and can monitor your dog for them. Do not start, stop, or change the dose of any cefpodoxime without first checking with your veterinarian. Cefpodoxime has no known serious interactions with other drugs. Although, some medications interact with cefpodoxime and reduce its absorption, so it is important to inform your vet of any medications (including supplements, vitamins, or herbal remedies) that your furry pal is taking.

Do not give Cefpodoxime at the same time as you are giving antacids like Maalox or other stomach acid reducers to your dog, as this can reduce the absorption and effectiveness of the medication. Keep a list of all the drugs your dog is taking and share this information with your veterinarian. Consult with your vet for other medical advice.

Any special considerations when giving cefpodoxime to dogs?

Despite the fact that cefpodoxime has been tested for safety in young puppies. Not enough studies have been conducted to confirm its safe use in breeding, pregnant, and lactating dogs. And it should only be used when necessary. Also, don’t administer cefpodoxime to dogs who are sensitive or allergic to penicillins, or other cephalosporins. Cefpodoxime should be used with care in dogs with seizure disorders or kidney disease.

Now that you have a thorough understanding of how this medication can help resolve your dog’s skin infection. You are ready to get Cefpodoxime for your dog. It is important to know that choosing the best product is a matter of evaluating your dog’s condition.

dog checking it's heartbeat

The next thing is to check with your vet. Your vet might consider a number of factors, such as the severity of your dog’s skin infection symptoms and your dog’s medical history. Including any allergies and antibiotics, he has recently taken, and possibly perform a urinalysis to find out the kind of bacteria causing the infection.

With all this information, your vet will recommend the right cefpodoxime that is safe for your furry pal and will help eliminate the problem. Cefpodoxime is safe and effective in treating canine skin infections. The once-daily dosage makes cefpodoxime a very convenient antibiotic for dog owners and also helps increase compliance. Treating the underlying factors and following the appropriate dose and duration of the antibiotic will prevent the recurrence of the disease.

Always make sure your dog has a safe and calm place to rest if they have a medical problem. For example, use a dog-proof trash can to avoid your dog getting infected by harmful bacteria in your trash.

terry wildogAuthor: Terry Wildog – Dr. Terry is a professional veterinarian with 10 years of medical experience. He currently splits his time between part-time vet practice and writing educational material for pet parents. A passionate animal lover and expert content writer. He spent his whole life with pets, especially dogs.

Images Canva and Pexels

This Post Has 2 Comments

  1. Michelle Williams

    Really hoping to find a fix for this awful skin issue. Poor Bella has been scratching like crazy for the past two days. At first I thought she had one or two fleas as we had a super long walk in taller grass and she can’t stand them, she’s super sensitive. When I started to brush her I noticed small red bumps on her belly. The verdict: skin infection, and a bad one. The vet recommended Cefpodoxime but I wanted to do my homework before administering such a powerful antibiotic. Thanks for being so thorough, doctor!

  2. Skylar

    Growing up I was surrounded by cats and dogs and 2021 was the first time I had to deal with a dog with skin infection. We’re still waiting for a diagnosis but by the looks of it he might have to go on antibiotics. Can you please suggest which of these 6 products is better suited for an older dog?

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